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Anti-epilepsy drug Depakote® (divalproex sodium) is used for the treatment of convulsions, migraines and bipolar disorder. In December 2009, the FDA issued an alert reminding health care professionals and patients about the increased risk of major birth defects such as spina bifida, limb defects, and cleft palate in unborn babies exposed to Depakote or other valproate related products during pregnancy.